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One of the most popular analgesics on the online market is currently Tramadol. Whereas many countries consider opioids to be controlled substances, this is not the case with Tramadol.
Tramadol has been in use as an analgesic since the late 1970s, and was a very popular analgesic in Germany. International interest in the medication resurfaced when researchers discovered that Tramadol acts similarly to opioids, but inhibits the re-uptake of serotonin and noradrenaline.
How Tramadol Works
Tramadol is a special medication that acts in a unique way. It can be distinguishable from other opioids due to its method of action and its safety profile. It possesses both opioid and non-opioid qualities, and is considered to be an atypical analgesic that acts centrally. Tramadol is a synthetic form of codeine, and does not have strong opioid agonist qualities. Similarly to antidepressant medications, it inhibits norepinephrine and serotonin reuptake.
The antidepressant venlafaxine is similar in structure to Tramadol. Some patients who suffer from chronic pain could experience an antidepressant effect from this drug.
As far as side effects are concerned, Tramadol does not cause many side effects; nausea and vomiting seem to be the most common side effects. When patients on Tramadol are given similar dosages to those of morphine and pethidine, respiratory depression does not normally occur. Respiratory effects of other medications can be increased when taking large doses of Tramadol. It has a low occurrence of cardiac depression and, unlike morphine, does not cause side effects such as dizziness and drowsiness.
The potential for abusing Tramadol or becoming dependent on it is not very high due to its weak opioid effect. Post-marketing data indicates that Tramadol does not have a high potential for abuse.
Urinary disorders, such as micturition difficulties and urinary retention, seem to be common in both Tramadol and other opioids.
People who have epilepsy should not take Tramadol, and people who take medication that lowers epileptic seizure thresholds should approach Tramadol with caution.
Uses of Tramadol
Tramadol can successfully treat moderate to severe pain, as well as neuropathic pain. This medicine possesses an efficacy whose dose-dependency is somewhere between dosages of codeine and morphine, with a parenteral strength that can be compared to that of pethidine.
Research indicates that more successful results can be obtained in controlling post operative pain when patients are given Tramadol instead of NSAIDs. Tramadol can be successfully combined with NSAIDs, because Tramadol’s method of action does not coincide with the mode of action in NSAIDs. Fewer side effects occur when the patient uses a combination of Tramadol and NSAIDs; the combination enables the dosage amount of Tramadol to be lowered.
Tramadol online can be especially useful in treating elderly people who suffer from osteoarthritis, because even though nonsteroidal anti-inflammatory medications can aggravate high blood pressure and cardiovascular symptoms, Tramadol does not possess this trait, nor does Tramadol cause peptic ulcers.
Tramadol has been successfully used, without the necessity of respiratory depression of the neonate, for managing labor pains. It can effectively treat pain that is caused by myocardial ischemia, renal colic or acute trauma.
Tramadol should be taken every 4 to 6 hours with a dosage between 50 and 100 mgs; the dosage of Tramadol should not exceed 400 mg per day; one single oral dosage of 100 mg of Tramadol has an analgesic effect for approximately 6 hours.
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